| Inter beat Napoli 3-2 (H) on 21 Nov 2021 |
| Napoli beat Udinese 4-0 (A) on 20 Sep 2021 |
| Udinese beat Spezia Calcio 1-0 (A) on 12 Sep 2021 |
| Spezia Calcio beat Torino 1-0 (H) on 6 Nov 2021 |
| Torino beat Sassuolo 1-0 (A) on 17 Sep 2021 |
| Sassuolo beat Juventus 2-1 (A) on 27 Oct 2021 |
| Juventus beat Fiorentina 1-0 (H) on 6 Nov 2021 |
| Fiorentina beat Milan 4-3 (H) on 20 Nov 2021 |
| Milan beat Atalanta 3-2 (A) on 3 Oct 2021 |
| Atalanta beat Salernitana 1-0 (A) on 18 Sep 2021 |
| Salernitana beat Venezia 2-1 (A) on 26 Oct 2021 |
| Venezia beat Roma 3-2 (H) on 7 Nov 2021 |
| Roma beat Genoa 2-0 (A) on 21 Nov 2021 |
| Genoa beat Cagliari 3-2 (A) on 12 Sep 2021 |
| Cagliari beat Sampdoria 3-1 (H) on 17 Oct 2021 |
| Sampdoria beat Empoli 3-0 (A) on 19 Sep 2021 |
| Empoli beat Bologna 4-2 (H) on 26 Sep 2021 |
| Bologna beat Hellas Verona 1-0 (H) on 13 Sep 2021 |
| Hellas Verona beat Lazio 4-1 (H) on 24 Oct 2021 |
| Lazio beat Inter 3-1 (H) on 16 Oct 2021 |
HWC: Thick arrows show the earliest chain of wins that passes through every team and returns to its start.