| Fortuna Köln beat Preußen Münster 3-2 (H) on 1 Oct 2021 |
| Preußen Münster beat SV 19 Straelen 4-0 (A) on 18 Sep 2021 |
| SV 19 Straelen beat Rot Weiss Essen 4-1 (A) on 20 Aug 2021 |
| Rot Weiss Essen beat Wuppertaler SV 1-0 (A) on 25 Aug 2021 |
| Wuppertaler SV beat Fortuna Düsseldorf II 2-1 (A) on 15 Sep 2021 |
| Fortuna Düsseldorf II beat Bonner 3-0 (A) on 25 Sep 2021 |
| Bonner beat Uerdingen 3-1 (A) on 21 Aug 2021 |
| Uerdingen beat Sportfreunde Lotte 2-0 (H) on 6 Oct 2021 |
| Sportfreunde Lotte beat Alemannia Aachen 1-0 (H) on 1 Oct 2021 |
| Alemannia Aachen beat Köln II 3-1 (A) on 15 Sep 2021 |
| Köln II beat Schalke 04 II 2-1 (A) on 15 Aug 2021 |
| Schalke 04 II beat Rot Weiss Ahlen 5-3 (H) on 14 Sep 2021 |
| Rot Weiss Ahlen beat VfB Homberg 2-1 (A) on 4 Sep 2021 |
| VfB Homberg beat SV Rödinghausen 1-0 (A) on 28 Aug 2021 |
| SV Rödinghausen beat SC Wiedenbrück 1-0 (H) on 1 Oct 2021 |
| SC Wiedenbrück beat Rot Weiß Oberhausen 1-0 (H) on 21 Aug 2021 |
| Rot Weiß Oberhausen beat Borussia Mönchengladbach II 3-2 (H) on 4 Sep 2021 |
| Borussia Mönchengladbach II beat SV Lippstadt 08 4-2 (H) on 28 Aug 2021 |
| SV Lippstadt 08 beat Wegberg Beeck 3-2 (A) on 11 Sep 2021 |
FLP: Thick arrows show the earliest chain of wins that passes through every team.